De Simone Formulation™

De Simone Formulation™

(Available as Visbiome in USA) and Vivomixx in Europe)

A proprietary, high-potency probiotic Product having 8 strains of live bacteria, clinically proven for gut health across all life stages – from neonates to adults – and for the management of intestinal and immune mediated disorders.

Importance of Gut Microbiota

  • Gut hosts trillions of beneficial bacteria supporting digestion, immunity, and pathogen defence
  • Healthy microbiota helps metabolize nutrients, detoxify harmful compounds, and strengthen immune development
  • Dysbiosis is linked to IBD, IBS, obesity, allergies, autoimmune disorders, and neurological conditions

Neonate, Infant & Adult Gut Microbiota

  • Gut colonization begins at birth and evolves through lactation, weaning, and adulthood
  • Early microbiota dominated by Bifidobacterium, later transitioning to Firmicutes and Bacteroidetes
  • Influenced by delivery mode, breastfeeding vs formula feeding, antibiotics, and diet
  • Early-life microbiota development represents a critical window for long-term immunity and disease prevention

Key Features

  • Available globally under brands such as Visbiome® (USA, India) and CDS-22 ™️(Europe), De Simone™️ (Korea)
  • 8 strains of live bacteria, up to 900 billion CFU per serving/pack
  • Backed by 100+ peer-reviewed clinical studies and over 20 years of research
  • Manufactured under proprietary strain ratios developed by Professor Claudio De Simone

8

Strains of Live Bacteria

900

billion CFU per serving/pack

100+

Peer-Reviewed Clinical Studies

20+

Years of Research

Benefits

  • Restores gut microbiome balance and strengthens intestinal barrier
  • Proven for management of IBS, Ulcerative Colitis, Pouchitis, and Hepatic Encephalopathy
  • Helps reduce intestinal permeability (“leaky gut”) linked to metabolic, immune, and neurological disorders
  • Supports healthy gut colonization and immune development in neonates and infants

Clinical Attributes

  • Strains include Lactobacillus, Bifidobacterium, and Streptococcus thermophilus
  • Cultured from proprietary Master Cell Banks and manufactured under stringent quality standards
  • Proven synergistic action between strains for maximum therapeutic efficacy

Dosing Formats

  • Capsules: 10 Billion (Bn), 45 Bn and 112.5 Bn
  • Powder Sachets: 225 or 450n CFU/sachet
  • Extra-Strength Sachets: 900Bn CFU (prescription only)
  • Drops: Easy-to-use format for neonates and infants (50B CFU per bottle)